Professeur Pierre PETIT

Équipe médicale :

Pharmacologie clinique et vigilances associées

Fonction :


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Psychiatrie polyvalente

Thérapies cognitives et comportementales

Ouvrages :

Petit P., Boulenger JP. : Indications frontières et dérives de prescription (Chapitre 18). In : Les Antidépresseurs. E. Corruble (ed.), Médecine Sciences Publications, Lavoisier, Paris, 2013, pp 205-215.

Petit P. Précis de Psychopharmacologie Médicale. Sauramps Médical Édition, Montpellier, 2011 (205 pages).


Principales publications des dix dernières années (2014-2004) :

Bardy G., Cathala P., Eiden C., Baccino E., Petit P., Mathieu O. An unusual case of death probably triggered by the association of buprenorphine at therapeutic dose with ethanol and benzodiazepines and with very low norbuprenorphine level. J Forensic Sci, 2014, sous presse.

Faillie JL., Babai S., Crépin S., Bres V., Laroche ML., Le Louet H., Petit P., Montastruc JL., Hillaire-Buys D. Pancreatitis associated with the use of GLP-1 analogs and DPP-4 inhibitors: a case/non-case study from the French Pharmacovigilance Database. Acta Diabetologica, 2014, 51, 491-497.

Faillie JL., Petit P., Montastruc JL., Hillaire-Buys D. Scientific evidence and controversies about pioglitazone and bladder cancer: which lessons can be drawn? Drug Safety, 2013, 36, 693-707.

Eiden C., Mathieu O., Cathala P., Debruyne D., Baccino E., Petit P., Peyriere H. Toxicity and death following recreational use of 2-pyrrolidino valerophenone. Clinical Toxicology, 2013, 51, 899-903.

Eiden C., Léglise Y., Bertomeu L., Clavel V., Faillie JL., Petit P., Peyrière H. New formulation of methadone for opioid dependence in France : Acceptability and diversion/misuse liability. Thérapie, 2013, 68, 107-111.

Vaquer G., Magous R., Cros G., Wojtusciszyn A., Renard E., Chevassus H., Petit P., Lajoix AD., Oiry C. Short-term intravenous insulin infusion is associated with reduced expression of NADPH oxidase p47phox subunit in monocytes from type 2 diabetes patients. Fundam. Clin. Pharmacol., 2013, 27, 669-671.

Chevassus H., Farret A., Gagnol JP., Ponçon CA., Costa F., Roux C., Galtier F., Petit P. Psychological and physiological effects of bupropion compared to methylphenidate after prolonged administration in healthy volunteers (NCT00285155). Eur. J. Clin. Pharmacol., 2013, 69, 779-787.

Hillaire-Buys D., Faillie JL., Montastruc JL., Petit P. Stay vigilant: a glitazone (pioglitazone) can hide a glitazar! Eur J Clin Pharmacol, 2012, 68, 1681-1683.

Leconet W., Petit P., Péraldi-Roux S., Bresson D. Non-viral delivery of small interfering RNA into pancreas-associated immune cells prevents autoimmune diabetes. Molecular Therapy, 2012, 20, 2315-2325.

Galtier F., Mura T., Raynaud de Mauverger E., Chevassus H., Farret A., Gagnol JP., Costa F, Dupuy A., Petit P., Cristol JP., Mercier J., Lacampagne A. Effect of a high dose of simvastatin on muscle mitochondrial metabolism and calcium signaling in healthy volunteers. Toxicol. Appl. Pharmacol., 2012, 263, 281-286.

Mezghenna K., Pomiès P., Chalançon A., Castex F., Niclaus N., Nadal B., Cambier L., Cazevielle C., Petit P., Gomis R., Berney T., Gross R, and Lajoix A.D. Increased neuronal NO synthase dimerization is involved in pancreatic beta cell hyperactivity in obesity. Diabetologia, 2011, 54, 2856-2866.

Youl E., Bardy G., Magous R., Cros G., Sejalon F., Virsolvy A., Richard S., Quignard JF., Gross R., Petit P., Bataille D., Oiry C. Quercetin potentiates insulin secretion and protects INS-1 pancreatic b-cells against oxidative damage via the ERK1/2 pathway. Br. J. Pharmacol, 2010, 161, 799-814.

Roux C., Chevassus H., Farret A., Costa F., Petit P., Galtier F. Selecting healthy volunteers in specific populations: a retrospective analysis of clinical and laboratory screening. Fundam. Clin. Pharmacol., 2010, 24, 121-127.

Chevassus H., Gaillard JB., Farret A, Costa F., Gabillaud I., Mas E., Dupuy AM., Michel F., Cantié C., Renard E., Galtier F., Petit P. A fenugreek seed extract selectively reduces spontaneous fat intake in overweight subjects. Eur. J. Clin. Pharmacol., 2010, 66, 449-455.

Petit P., Lajoix AD., Gross R. P2 purinergic signalling in the pancreatic β-cell: control of insulin secretion and pharmacology. Eur. J. Pharm. Sci., 2009, 37, 67-75.

Chevassus H., Molinier N., Costa F., Galtier F., Renard E., Petit P. A fenugreek seed extract selectively reduces spontaneous fat consumption in healthy volunteers. Eur J Clin Pharmacol, 2009, 65, 1175-1178.

Faruque OM., Le-Nguyen D., Lajoix AD., Vives E., Petit P., Bataille D., Hani EH. Cell-Permeable Peptide-based Disruption of Endogenous PKA-AKAP Complexes: A Tool for Studying the Molecular Roles of AKAP-mediated PKA Subcellular Anchoring. Am. J. Physiol.-Cell Physiol., 2009, 296, C306-316.

Tousch D., Lajoix AD., Hosy E., Azay-Milhau J., Ferrare K., Jahannault C., Cros G., Petit P.: Chicoric acid, a new compound able to enhance insulin release and glucose uptake. Biochem. Biophys. Res. Commun., 2008, 377(1),131-135.

Lugo-Garcia L., Nadal B., Gomis R., Petit P., Gross R., Lajoix A.D.: Human pancreatic islets express the purinergic P2Y11 and P2Y12 receptors. Horm. Metab. Res., 2008, 40, 827-830.

Farret A., Chevassus H., Roux B., Petit P., Galtier F.: Direct rosiglitazone-induced modifications in insulin secretion, action and clearance: a single dose, hyperglycaemic clamp study. Diabetologia, 2007, 50, 1384-1387.

Lugo-Garcia L., Filhol R., Lajoix A-D., Gross R., Petit P., Vignon J.: Expression of purinergic P2Y receptor subtypes by INS-1 insulinoma β-cells: a molecular and binding characterization. Eur. J. Pharmacol., 2007, 568, 54-60.

Lajoix A-D., Badiou S., Péraldi-Roux S., Chardès T., Dietz S., Aknin C., Tribillac F., Petit P., Gross R.: Protein inhibitor of a neuronal nitric oxide synthase (PIN) is a new regulator of glucose induced-insulin secretion. Diabetes, 2006, 55, 3279-3288.

Farret A., Filhol R., Linck N., Manteghetti M., Vignon J., Gross R., Petit P.: P2Y receptor mediated modulation of insulin release by a novel generation of 2-substituted-5’-O-(1-boranotriphosphate)-adenosine analogues. Pharm. Res., 2006, 23, 2665-2671.

Farret A., Lugo-Garcia L., Galtier F., Gross R., Petit P. Pharmacological interventions that directly stimulate or modulate insulin secretion from pancreatic b-cell: implications for the treatment of type 2 diabetes. Fundam. Clin. Pharmacol., 2005, 19, 647-656.

Léon C., Freund M., Latchoumanin O., Farret A., Petit P., Cazenave P., Gachet C.: The P2Y1 receptor is involved in the maintenance of glucose homeostasis and in insulin secretion in mice. Purinergic Signalling, 2005, 1, 145-151.

Montpied P., Domingo N., Senft M., Portugal H., Petit P., Chanussot F.: High-fat diets impede the lowering effect of cyclosporin A on rat brain lipids and interact with the expression of apolipoproteins E and J. Lipids, 2005, 40, 59-67.

Chapal N., Molina L., Molina F., Laplanche M., Pau B., Petit P. : Pharmacoproteomic approach to the study of drug mode of action, toxicity, and resistance: applications in diabetes and cancer. Fundam. Clin. Pharmacol., 2004, 18, 413-422.

Farret A., Vignaud M., Dietz S., Vignon J., Petit P., Gross R. : P2Y purinergic potentiation of glucose-induced insulin secretion and pancreatic b-cell metabolism. Diabetes, 2004, 53 (Suppl 3), S63-S66.

Rchid H., Chevassus H., Nmila R., Guiral C., Petit P., Chokaïri M., Sauvaire Y. Nigella sativa seed extracts enhance glucose-induced insulin release from rat isolated Langerhans islets. Fundam. Clin. Pharmacol., 2004, 18, 525-529.

Lajoix A.D., Pugnière M., Roquet F., Mani J.C., Dietz S., Linck N., Faurie F., Ribes G., Petit P., Gross R : Changes in the dimeric state of neuronal NO synthase affect the kinetics of secretagogue-induced insulin response. Diabetes, 2004, 53, 1467-1474.

Broca C., Breil V., Cruciani-Guglielmacci C., Manteghetti M., Rouault C., Derouet M., Rizkalla S., Pau B., Petit P., Ribes G., Ktorza A., Gross R., Reach G., Taouis M.: The insulinotropic agent ID1101 (4-hydroxyisoleucine) activates insulin signaling in rat. Am. J. Physiol. (Endocrinol. Metab.), 2004, 287, E463-E471.

Chevassus H., Mourand I., Molinier N., Lacarelle B., Brun J.F., Petit P.: Assessment of single-dose benzodiazepines on insulin secretion, insulin sensitivity and glucose effectiveness in healthy volunteers: a double-blind, placebo-controlled, randomized cross-over trial [ISRCTN08745124]. BMC Clin. Pharmacol., 2004, 4 :3 (pp. 1-10). 

Pharmacologie expérimentale et pharmacologie clinique (psychopharmacologie et pharmacologie endocrino-métabolique)