Doctor Pascal AMEDRO

Service:

Pédiatrie multidisciplinaire

Medical team:

Cardiologie et pneumologie pédiatrique

Function:

PRATICIEN HOSPITALIER

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Secrétariat 04 67 33 66 39

Consultations de cardiologie pédiatrique (0-18 ans) 04 67 33 66 43

Plateau technique pédiatrique 04 67 33 60 34

Consultations cardiopathies congénitales à l'âge adulte 04 67 33 61 85

Tests d'effort cardio-respiratoires congénitaux adultes 04 67 33 59 11

Attachés de Recherche Clinique 04 67 33 66 32
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Médecin Coordonnateur du Centre de Compétences Malformations Cardiaques Congénitales Complexes (M3C)

Cardiologie Pédiatrique et Congénitale Adulte

Malformations cardiaques de l'enfant et de l'adulte.

Cardiologie de l'enfant

Cardiopathies congénitales, syncopes, malaises de l'enfant, maladies cardiaques rares de l'enfant (QT long congénital, syndrome de Brugada, dysplasie arythmogène du ventricule droit, tachycardie ventriculaire catécholergique, cardiomyopathie dilatées, cardiomyopathie hypertrophique, etc.), hypertension pulmonaire sévère de l'enfant (HTAP).

Cardiopathies congénitales de l'adulte

Malformations cardiaques congénitales complexes (réseau maladies rares M3C).

Hypertension artérielle pulmonaire associée à une cardiopathie congénitale de l'enfant et de l'adulte (réseaux maladies rares HTAP-M3C).

Lien ORPHANET : http://www.orpha.net/consor/cgi-bin/Clinics_Search.php?lng=FR&data_id=62378&Centres experts=Reference-centre-for-complex-congenital-heart-defects---Competence-centre&title=Reference-centre-for-complex-congenital-heart-defects---Competence-centre&search=Directory_Professionals_Simple

Cardiologie Pédiatrique et Congénitale Adulte

Médecin Coordonnateur du Département de Pédiatrie

Responsable d'Equipe Médicale de Pédiatrie Spécialisée (Pôle Femme-Mère-Enfant)

Responsable d'Equipe Médicale des Cardiopathies Congénitales de l'Adulte (Pôle Coeur-Poumons)

Médecin Coordonnateur du Centre de Compétences Malformations Cardiaques Congénitales Complexes (M3C)

https://www.ncbi.nlm.nih.gov/pubmed/?term=Amedro%20P%5BAuthor%5D&cauthor=true&cauthor_uid=29170358

  1. Schouvey S, Dragulescu A, Ghez O, Amedro P, Kreitmann B, Chetaille P, Fraisse A and Metras D. [Rehabilitation of hypoplastic pulmonary arteries in pulmonary atresia with ventricular septal defect. Medium term results]. Arch Mal Coeur Vaiss. 2007;100:422-7.
  2. Eiden C, Peyriere H, Tichit R, Cociglio M, Amedro P, Blayac JP, Margueritte G and Hillaire-Buys D. Inherited long QT syndrome revealed by antifungals drug-drug interaction. J Clin Pharm Ther. 2007;32:321-4.
  3. Paoli F, Dragulescu A, Amedro P, Ovaert C, Mas B, Ghez O, Metras D, Kreitmann B and Fraisse A. [A monocenter experience of ventricular septal defects treated by catherization]. Arch Mal Coeur Vaiss. 2007;100:380-5.
  4. Dragulescu A, Ghez O, Fraisse A, Gaudart J, Amedro P, Kreitmann B and Metras D. [Long-term results of complete atrio-ventricular canal correction]. Arch Mal Coeur Vaiss. 2007;100:416-21.
  5. Hugues N, Abadir S, Dragulescu A, Nassi C, Errera J, Amedro P, Ghez O and Fraisse A. Transcatheter perforation followed by pulmonary valvuloplasty in neonates with pulmonary atresia and ventricular septal defect. Arch Cardiovasc Dis. 2009;102:427-32.
  6. Blanchet C, Nicollas R, Bigorre M, Amedro P and Mondain M. Management of infantile subglottic hemangioma: acebutolol or propranolol? Int J Pediatr Otorhinolaryngol. 2010;74:959-61.
  7. Dragulescu A, Kammache I, Fouilloux V, Amedro P, Metras D, Kreitmann B and Fraisse A. Long-term results of pulmonary artery rehabilitation in patients with pulmonary atresia, ventricular septal defect, pulmonary artery hypoplasia, and major aortopulmonary collaterals. J Thorac Cardiovasc Surg. 2011;142:1374-80.
  8. Rideau Batista Novais A, Matecki S, Jaussent A, Picot MC, Amedro P, Guillaumont S, Picaud JC and Cambonie G. Hyperventilation during exercise in very low birth weight school-age children may implicate inspiratory muscle weakness. The Journal of pediatrics. 2012;160:415-420 e1.
  9. Amedro P, Dorka R, Moniotte S, Guillaumont S, Fraisse A, Kreitmann B, Borm B, Bertet H, Barrea C, Ovaert C, Sluysmans T, De La Villeon G, Vincenti M, Voisin M, Auquier P and Picot MC. Quality of Life of Children with Congenital Heart Diseases: A Multicenter Controlled Cross-Sectional Study. Pediatric cardiology. 2015;36:1588-1601.
  10. Gouton M, Nizard J, Patel M, Sassolas F, Jimenez M, Radojevic J, Mathiron A, Amedro P, Barre E, Labombarda F, Vaksmann G, Chantepie A, Le Gloan L and Ladouceur M. Maternal and fetal outcomes of pregnancy with Fontan circulation: A multicentric observational study. International journal of cardiology. 2015;187:84-9.
  11. Amedro P, Picot MC, Moniotte S, Dorka R, Bertet H, Guillaumont S, Barrea C, Vincenti M, De La Villeon G, Bredy C, Soulatges C, Voisin M, Matecki S and Auquier P. Correlation between cardio-pulmonary exercise test variables and health-related quality of life among children with congenital heart diseases. International journal of cardiology. 2016;203:1052-60.
  12. Amedro P, Basquin A, Gressin V, Clerson P, Jais X, Thambo JB, Guerin P, Cohen S and Bonnet D. Health-related quality of life of patients with pulmonary arterial hypertension associated with CHD: the multicentre cross-sectional ACHILLE study. Cardiology in the young. 2016:1-10.
  13. Amedro P, Soulatges C, Fraisse A. Infective Endocarditis After Device Closure of Atrial Septal Defects: Case Report and Review of the Literature. Catheter Cardiovasc Interv. 2017 Feb 1;89(2):324-334
  14. Amedro P, Gavotto A, Bredy C, Guillaumont S.Cardiac rehabilitation for children and adults with congenital heart disease. Presse Med. 2017 May;46(5):530-537
  15. Ladouceur M, Benoit L, Basquin A, Radojevic J, Hauet Q, Hascoet S, Moceri P, Le Gloan L, Amedro P, Lucron H, Richard A, Gouton M, Nizard J. How Pregnancy Impacts Adult Cyanotic Congenital Heart Disease: A Multicenter Observational Study. Circulation. 2017 Jun 13;135(24):2444-2447
  16. Hascoet S, Fournier E, Jaïs X, Le Gloan L, Dauphin C, Houeijeh A, Godart F, Iriart X, Richard A, Radojevic J, Amedro P, Bosser G, Souletie N, Bernard Y, Moceri P, Bouvaist H, Mauran P, Barre E, Basquin A, Karsenty C, Bonnet D, Iserin L, Sitbon O, Petit J, Fadel E, Humbert M, Ladouceur M. Outcome of adults with Eisenmenger syndrome treated with drugs specific to pulmonary arterial hypertension: A French multicentre study. Arch Cardiovasc Dis. 2017 May;110(5):303-316
  17. Amedro P, Tahhan N, Bertet H, Jeandel C, Guillaumont S, Mura T and Picot MC. Health-related quality of life among children with Turner syndrome: controlled cross-sectional study. J Pediatr Endocrinol Metab. 2017;30:863-868.
  18. Amedro P, Bajolle F, Bertet H, Cheurfi R, Lasne D, Nogue E, Auquier P, Picot MC, Bonnet D. Quality of life in children participating in a non-selective INR self-monitoring VKA-education program. Arch Cardiovasc Dis. 2018 Mar;111(3):180-188
  19. Amedro P, Gavotto A, Guillaumont S, Bertet H, Vincenti M, De La Villeon G, Bredy C, Acar P, Ovaert C, Picot MC, Matecki S. Cardiopulmonary fitness in children with congenital heart diseases versus healthy children. Heart. 2018 Jun;104(12):1026-1036
  20. Amedro P, Guillaumont S, Bredy C, Matecki S, Gavotto A. Atrial septal defect and exercise capacity: value of cardiopulmonary exercise test in assessment and follow-up. J Thorac Dis. 2018 Sep;10(Suppl 24):S2864-S2873. 
  21. Romieu H, Charbonnier F, Janka D, Douillard A, Macioce V, Lavastre K, Abassi H, Renoux MC, Mura T, Amedro P. Efficiency of physiotherapy with Caycedian Sophrology on children with asthma: A randomized controlled trial. Pediatr Pulmonol. 2018 May;53(5):559-566.
  22. Hascoet S, Boet A, Nubret K, Lilot M, Feuillet S, Benbrik N, Guihaire J, Le Bret E, Fadel E, Fouilloux V, Amedro P, Houyel L, Kreitmann B. Extracorporeal life support and heart-lung transplant in children. Presse Med. 2018 Jul - Aug;47(7-8 Pt 1):611-619.
  23. Marcadet DM, Pavy B, Bosser G, Claudot F, Corone S, Douard H, Iliou MC, Vergès-Patois B, Amedro P, Le Tourneau T, Cueff C, Avedian T, Solal AC, Carré F. French Society of Cardiology: Guidelines on Exercise Tests Part I: Methods and interpretation. Arch Cardiovasc Dis. 2018 Dec;111(12):782-790.
  24. Marcadet DM, Pavy B, Bosser G, Claudot F, Corone S, Douard H, Iliou MC, Vergès-Patois B, Amedro P, Le Tourneau T, Cueff C, Avedian T, Solal AC, Carré F. French Society of Cardiology: Guidelines on Exercise Tests Part II: Indications for exercise tests in cardiac diseases. Arch Cardiovasc Dis. 2019 Jan;112(1):56-66.
  25. Bredy C, Soulatges C, Guillaumont S, Vincenti M, De La Villeon G, Mura T, Amedro P. How should we determine normal echocardiographic right ventricle function reference values in pediatrics? Int J Cardiovasc Imaging. 2018 Sep 29. doi: 10.1007/s10554-018-1462-6.
  26. Amedro P, Gavotto A, Gelibert D, Fraysse V, De La Villeon G, Vandenberghe D and Bredy C. Feasibility of clinical hypnosis for transesophageal echocardiography in children and adolescents. Eur J Cardiovasc Nurs. 2019 Feb;18(2):163-170.
  27. Corone S, Bosser G, Legendre A, Guillaumont S and Amedro P. [Cardiac rehabilitation in adults with congenital heart diseases]. Ann Cardiol Angeiol (Paris). 2018 Nov;67(5):345-351.
  28. Hascoet S, Hadeed K, Karsenty C, Dulac Y, Heitz F, Combes N, Chausseray G, Alacoque X, Auriol F, Amedro P, Fraisse A and Acar P. Feasibility, Safety and Accuracy of Echocardiography-Fluoroscopy Imaging Fusion During Percutaneous Atrial Septal Defect Closure in Children. J Am Soc Echocardiogr. 2018 Nov;31(11):1229-1237.
  29. Fraisse A, Latchman M, Sharma SR, Bayburt S, Amedro P, Di Salvo G, Baruteau AE. (2018). Atrial septal defect closure: indications and contra-indications, J Thorac Dis 2018;10(Suppl 24):S2874-S2881.
  30. Tahhan N, Amedro P. Evaluation of cardiac MRI and ambulatory blood pressure monitoring in a pediatric Turner syndrome population. Progress in Pediatric Cardiology, 2018 ; In Press.
  31. Maffre I, Amedro P. Diazoxide causality assessment of a pericardial effusion in a child with Kabuki syndrome. J Clin Res Pediatr Endocrinol 2019 May 28;11(2):218-219. 
  32. Amedro P, Bredy C, Guillaumont S, De La Villeon G, Gamon L, Lavastre K, Meli AC, Richard S, Cazorla O, Lacampagne A, Mura T, Vincenti M. Speckle tracking echocardiography in healthy children: comparison between the QLAB by Philips and the EchoPAC by General Electric. Int J Cardiovasc Imaging. 2019 May;35(5):799-809.
  33. Amedro P, Gavotto A, Legendre A, Lavastre K, Bredy C, De La Villeon G, Matecki S, Vandenberghe D, Ladeveze M, Bajolle F, Bosser G, Bouvaist H, Brosset P, Cohen L, Cohen S, Corone S, Dauphin C, Dulac Y, Hascoet S, Iriart X, Ladouceur M, Mace L, Neagu O, Ovaert C, Picot MC, Poirette L, Sidney F, Soullier C, Thambo JB, Combes N, Bonnet D, Guillaumont S. Impact of a centre and home-based cardiac rehabilitation program on the quality of life of teenagers and young adults with congenital heart disease: the QUALI-REHAB study rationale, design and methods. Int J Cardiol. 2019 May 15;283:112-118.
  34. Amedro P, Vincenti M, De La Villeon G, Lavastre K, Barrea C, Guillaumont S, Bredy C, Gamon L, Meli A, Cazorla O, Fauconnier J, Meyer P, Rivier F, Adda J, Mura T, Lacampagne A. Speckle Tracking Echocardiography in Children with Duchenne Muscular Dystrophy: a Prospective Multicenter Controlled Cross-sectional Study. J Am Soc Echocardiogr 2019 Mar;32(3):412-422.
  35. Le Roy J, Vernhet Kovacsik H, Zarqane H, Vincenti M, Abassi H, Lavastre K, Mura T, Lacampagne A, Amedro P. Ultra-Low Dose Multiphasic Coronary Computed Tomography Angiography for Pediatric Patients with Congenital Heart Diseases. Circ Cardiovasc Imaging. 2019 Feb;12(2):e008348.
  36. Amedro P, Bayburt S, Assaidi A, Kreitmann B, Habib G, Fouilloux V, Fraisse A. Should transcatheter closure of atrial septal defects with inferior-posterior deficient rim still be attempted? J Thorac Dis. 2019 Mar;11(3):708-716.
  37. Vincenti M, Guillaumont S, Clarivet B, Macioce V, Mura T, Boulot P, Cambonie G, Amedro P. Prognosis of severe congenital heart diseases: do we overestimate the impact of prenatal diagnosis? Arch Cardiovasc Dis. 2019;Apr;112(4):261-269. 
  38. Abassi H, Gavotto A, Picot MC, Bertet H, Matecki S, Guillaumont S, Moniotte S, Auquier P, Moreau J, Amedro P. Impaired pulmonary function and its association with clinical outcomes, exercise capacity and quality of life in children with congenital heart disease. Int J Cardiol. 2019;Jun 15;285:86-92.
  39. Lavilledieu D, Abassi H, Mercier G, Guiraud M, Chaffaut GD, Milesi C, Cambonie G, Gavotto A, Jeziorski E and Amedro P. Implementation of an organizational infrastructure paediatric plan adapted to bronchiolitis epidemics. J Infect Public Health. 2020;Feb;13(2):167-172
  40. Amedro P and Vincenti M. Response to the letter about the article "Prognosis of severe congenital heart diseases: Do we overestimate the impact of prenatal diagnosis?". Arch Cardiovasc Dis. 2019;112:365-366.
  41. Gavotto A, Muanza B, Delion F, Dusacre JA and Amedro P. Chikungunya disease among infants in French West Indies during the 2014 outbreak. Arch Pediatr. 2019;26:259-262.
  42. Gavotto A, Abassi H, Rola M, Serrand C, Picot MC, Iriart X, Thambo JB, Iserin L, Ladouceur M, Bredy C and Amedro P. Factors associated with exercise capacity in patients with a systemic right ventricle. International journal of cardiology. 2019;292:230-235.
  43. Werner O, El Louali F, Fouilloux V, Amedro P, Ovaert C. Parental anxiety before invasive cardiac procedure in children with congenital heart disease: Contributing factors and consequences. Congenit Heart Dis. 2019 Sep;14(5):778-784.
  44. Werner O, Abassi H, Lavastre K, Guillaumont S, Picot MC, Serrand C, Dulac Y, Souletie N, Acar P, Bredy C and Amedro P. Factors influencing the participation of adolescents and young adults with a congenital heart disease in a transition education program: A prospective multicentre controlled study. Patient Educ Couns. 2019 Dec;102(12):2223-2230.
  45. Mahe P, Nagot N, Portales P, Lozano C, Vincent T, Sarda P, Perez MJ, Amedro P, Marin G and Jeziorski E. Risk factors of clinical dysimmune manifestations in a cohort of 86 children with 22q11.2 deletion syndrome: A retrospective study in France. Am J Med Genet A. 2019;179:2207-2213.
  46. Monagle P, Lensing AWA, Thelen K, Martinelli I, Male C, Santamaria A, Samochatova E, Kumar R, Holzhauer S, Saracco P, Simioni P, Robertson J, Grangl G, Halton J, Connor P, Young G, Molinari AC, Nowak-Gottl U, Kenet G, Kapsa S, Willmann S, Pap AF, Becka M, Twomey T, Beyer-Westendorf J, Prins MH, Kubitza D and Investigators EI-JP. Bodyweight-adjusted rivaroxaban for children with venous thromboembolism (EINSTEIN-Jr): results from three multicentre, single-arm, phase 2 studies. Lancet Haematol. 2019;6:e500-e509.
  47. Male C, Lensing AWA, Palumbo JS, Kumar R, Nurmeev I, Hege K, Bonnet D, Connor P, Hooimeijer HL, Torres M, Chan AKC, Kenet G, Holzhauer S, Santamaria A, Amedro P, Chalmers E, Simioni P, Bhat RV, Yee DL, Lvova O, Beyer-Westendorf J, Biss TT, Martinelli I, Saracco P, Peters M, Kallay K, Gauger CA, Massicotte MP, Young G, Pap AF, Majumder M, Smith WT, Heubach JF, Berkowitz SD, Thelen K, Kubitza D, Crowther M, Prins MH, Monagle P and Investigators EI-JP. Rivaroxaban compared with standard anticoagulants for the treatment of acute venous thromboembolism in children: a randomised, controlled, phase 3 trial. Lancet Haematol. 2019 Jan;7(1):e18-e27.
  48. Le Roy J, Zarqane H, Azais B, Vernhet Kovacsik H, Mura T, Okerlund D, Lacampagne A, Amedro P. Impact of motion correction algorithms on image quality in children undergoing coronary CT angiography: a comparison with regular monophasic and multiphasic acquisitions. Circ Cardiovasc Imaging. 2019. Dec;12(12):e009650.
  49. Gavotto A, Ousselin A, Pidoux O, Cathala P, Costes-Martineau V, Rivière B, Pasquié JL, Amedro P, Rambaud C, Cambonie G. Respiratory syncytial virus-associated mortality in a healthy 3-year-old child: a case report. BMC Pediatr. 2019 Nov 27;19(1):462.
  50. Werner O, Ovaert C, Amedro P. Acquired systemic-to-pulmonary shunts in a 6-month-old child: case report and review of the literature. Cardiol Young. 2020 Mar;30(3):427-430.
  51.  Gavotto A, Werner O, Amedro P. Late infective endocarditis after transcatheter tricuspid valve-in-valve implantation: A pediatric case report. Arch Pediatr. 2020 Feb;27(2):107-109
  52. Amedro P, Gavotto A, Abassi H, Picot MC, Matecki S, Malekzadeh-Milani S, Levy M, Ladouceur M, Ovaert C, Aldebert P, Thambo JB, Fraisse A, Humbert M, Cohen S, Baruteau AE, Karsenty C, Bonnet D, Hascoet S; SV-INHIBITION study investigators. Efficacy of phosphodiesterase type 5 inhibitors in univentricular congenital heart disease: the SV-INHIBITION study design. ESC Heart Fail. 2020 Mar 9. doi: 10.1002/ehf2.12630. [Epub ahead of print]
  53. Moreau J, Lavastre K, Romieu H, Charbonnier F, Guillaumont S, Bredy C, Abassi H, Werner O, De La Villeon G, Requirand A, Auer A, Matecki S, Karsenty C, Guitarte A, Hadeed K, Dulac Y, Souletie N, Acar P, Bajolle F, Bonnet D, Negre-Pages L, Mura T, Mounier M, Seguela PE, Thomas J, Iriart X, Thambo JB, Amedro P. Impact of Sophrology on cardiopulmonary fitness in teenagers and young adults with a congenital heart disease: the SOPHROCARE study rationale, design and methods. Int J Cardiol Heart Vasc. Volume 27, April 2020, 100489.
  54. Gavotto A, Thomas F, Werner O, Moreau J, Amedro P. Use of treprostinil in pediatric pulmonary hypertension: case reports and review of the literature. J Cardiovasc Pharmacol. 2020 Mar 9. doi: 10.1097/FJC.0000000000000820. [Epub ahead of print]
  55. Young G, Lensing AWA, Monagle P, Male C, Thelen K, Willmann S, Palumbo JS, Kumar R, Nurmeev I, Hege K, Bajolle F, Connor P, Hooimeijer HL, Torres M, Chan AKC, Kenet G, Holzhauer S, Santamaría A, Amedro P, Beyer-Westendorf J, Martinelli I, Patricia Massicotte M, Smith WT, Berkowitz SD, Schmidt S, Price V, Prins MH, Kubitza D; EINSTEIN-Jr. Phase 3 Investigators. Rivaroxaban for treatment of pediatric venous thromboembolism. An Einstein-Jr Phase 3 dose-exposure-response evaluation. J Thromb Haemost. 2020 Apr 4. doi: 10.1111/jth.14813. [Epub ahead of print]
  56. Gavotto A, Vandenberghe D, Abassi H, Bertet H, Macioce V, Picot MC, Guillaumont S, Matecki S, Amedro P. The oxygen uptake efficiency slope: a reliable surrogate parameter for exercise capacity in healthy and cardiac children? Archives of Disease in Childhood. April 2020 (accepted for publication).

Attachés de Recherche Clinique : Tél 04 67 33 66 32 ou recherche-clinique-ccp@chu-montpellier.fr 

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