Publications

Le CIC est une plate-forme d'investigation clinique ouverte aux cliniciens, aux chercheurs fondamentalistes et aux promoteurs industriels et institutionnels. Il constitue un lieu d'expertise et de savoir-faire. Les moyens humains et techniques mis à disposition permettent de mener une recherche clinique conforme aux exigences de l'assurance qualité, dans le respect des règles éthiques et juridiques, aboutissant à une valorisation optimale. La recherche clinique au CIC concerne de façon principale : le diabète et les anomalies du métabolisme, les pathologies neurologiques et psychiatriques, les maladies infectieuses et les vaccinations, les pathologies pédiatriques. Le caractère pluri-thématique du CIC lui permet cependant de mener des recherches cliniques dans toutes les pathologies humaines.

Articles originaux dans des revues internationales :

  • Renard E, Place J, Cantwell M, Chevassus H, Palerm C. Closed-Loop Insulin Delivery Using a Subcutaneous Glucose Sensor and Intra-Peritoneal Insulin Delivery: A Feasibility Study Testing a New Model for the Artificial Pancreas. Diabetes Care, 2010, 33 (1) : 121-127. Epub 2009 Oct 21.(IF 6.718).
  • Chevassus H, Gaillard JB, Farret A, Costa F, Gabillaud I, Mas E, Dupuy AM, Michel F, Cantie C, Renard E, Galtier F, Petit P,. A fenugreek seed extract selectively reduces spontaneous fat intake in overweight subjects. European Journal of Clinical Pharmacology, 2010, Epub 2009 Dec 18. (IF 2.743).
  • Maïmoun L, Coste O, Galtier F, Mura T, Mariano-Goulart D, Paris F, Sultan C. Bone mineral density acquisition in peripubertal female rhythmic gymnasts is directly associated with plasma IGF-1/IGFBP-3 ratio. EJE, 2010, 163 (1); 157-64. (IF 3.539)
  •  Maldonado IL, Machi P, Costalat V, Mura T, Bonafé A. Neuroform stent-assisted coiling of unruptured intracranial aneurysms: a single center experience with acute and midterm results. AJNR 2010, in press. (IF 3.296) 
  • Galtier F,. Gestational diabetes mellitus. Definition, epidemiology, risk factors. Diabetes and metabolism, 2010, 36 (6) ; 628-651 (IF 2.426)
  •  Maïmoun L, Coste O, Mariano-Goulart D, Galtier F, Mura T, Philibert P, Briot K, Paris F, Sultan C. In peripubertal girls, artistic gymnastic improves areal bone mineral density and femoral bone geometry without affecting the OPG/RANKL system. Osteoporosis Int, in press (IF 4.997) 
  • Benlakhal F, Mura T, Schved JF, Giansily-Blaizot M. A retrospective analysis of 157 surgical procedures performed without replacement therapy in 83 unrelated factor VII-deficient patients. J Thromb Haemost. (IF 6.069) 
  • Sivananthan S, Naumova V, Man CD, Facchinetti A, Renard E, Cobelli C, Pereverzyev SV. Assessment of Blood Glucose Predictors: The Prediction-Error Grid Analysis. Diabetes Technol Ther 2011 May 25, 13(8): 787-796 (IF 2.146) 
  • Renard E, Dubois-Laforgue D, Guerci B, on behalf of the Variability Study Group. Non inferiority of insulin glargine versus insulin detemir on blood glucose variability in type 1 diabetic patients: A multi-centre, randomized, cross-over study. Diabetes Technol Ther 2011 (in press). (IF 2.146)
  •  Cobelli C, Renard E, Kovatchev B. Artificial pancreas: past, present, future. Diabetes 2011; 60(11): 2672-82 (IF 8.889) 
  • Vergès B, Bonnard C, Renard E,. Beyond glucose lowering: Glucagon-like peptide-1 receptor agonists, body weight and cardiovascular system. Diabetes Metab 2011 (under revision) (IF 2.426) 
  • Coste O, Paris F, Galtier F, Letois F, Maïmoun L, Sultan C. Polycystic ovary-like syndrome in adolescent competitive swimmers. Fertil Steril 2011 Aug 4; 96(4): 1037-42. (IF 3.122) 
  • Mehta SS, Doumane G, Mura T, Nocca D, Fabre JM. Laparoscopic versus open distal pancreatectomy: a single-institution case-control study. Surg Endosc. 2011 Sep 10. [Epub ahead of print] (IF 3.307) 
  • Loulergue P, Duval X, Galtier F, Lenzi N, Laurichesse H, Launay O. Questions for Biotechs: REIVAC. Hum Vaccin 2011 Feb 1; 7(2): 142-3 (IF 2.042)
  •  Nocca D, Guillaume F, Noel P, Picot MC, Aggarwal R, El Kamel M, Schaub R, de Seguin de Hons C, Renard E, Fabre JM. Impact of laparoscopic sleeve gastrectomy and laparoscopic gastric bypass on HbA1c blood level and pharmacological treatment of type 2 diabetes mellitus in severe or morbidly obese patients. Results of a multicenter prospective study at 1 year. Obes Surg. 2011; 21(6):738-43. (IF: 3.102 SIGAPS: B)
  • Baghdadli A, Assouline B, Sonie S, Pernon E, Darrou C, Michelon C, Picot MC, Aussilloux C and Pry R. Developmental trajectories of adaptive behaviors from early childhood to adolescence in a cohort of 152 children with autism spectrum disorders. J Autism Dev Disord. 2011 1314-25 (IF: 3.699 SIGAPS: B) .
  • Olie E, Picot MC, Guillaume S, Abbar M and Courtet P. Measurement of total serum cholesterol in the evaluation of suicidal risk. J Affect Disord 2011. 133(1-2), 234-8 (IF: 3.295 SIGAPS: C).
  • Cavalier A, Picot MC, Artiaga C, Mazurier E, Amilhau MO, Froye E, et al. Prevention of deformational plagiocephaly in neonates. Early Hum Dev 2011;87:537-43. (IF:2.046 SIGAPS:C).
  • Kluger N, Letois F, Picot MC, Guillot B, Bessis D. How much disability is caused by fibrofolliculomas during Birt-Hogg-Dubé Syndrome? J Eur Acad Dermatol Venereol 2011;25:940-4. (IF:2.98 SIGAPS:B ).
  • Clarke WL, Renard E,. Clinical Requirements for Closed-Loop Control Systems. J Diabetes Sci Technol 2012; 6(2):444-52.
  •  Patek SD, Magni L, Dassau E, Hughes CS, Toffanin C, De Nicolao G, Breton M, Dalla Man C, Renard E, Zisser H, Doyle III FJ, Cobelli C, Kovatchev BP. Modular Closed-Loop Control of Diabetes. IEEE, Trans of Biomed Eng 2012 Apr 3. [Epub ahead of print] (IF 1.790).
  • Humbertclaude V, Hamroun D, Bezzou K, Bérard C, Boespflug-Tanguy O, Bommelaer C, Campana-Salort E, Cances C, Chabrol B, Commare MC, Cuisset JM, de Lattre C, Desnuelle C, Echenne B, Halbert C, Jonquet O, Labarre-Vila A, N'guyen-Morel MA, Pages M, Pepin JL, Petitjean T, Pouget J, Ollagnon-Roman E, Richelme C, Rivier F, Sacconi S, Tiffreau V, Vuillerot C, Picot MC, Claustres M, Béroud C, Tuffery-Giraud S. Motor and respiratory heterogeneity in Duchenne patients: Implication for clinical trials. Eur J Paediatr Neurol. Eur J Paediatr Neurol 2012;16:149-60 (IF:1.982 SIGAPS:C ).
  •  Faure S, Herrero A, Jung B, Duny Y, Daures JP, Mura T, Assenat E, Bismuth M, Bouyabrine H, Donnadieu-Rigole H, Navarro F, Jaber S, Larrey D, Pageaux GP. Excessive alcohol consumption after liver transplantation impacts on long-term survival, whatever the primary indication. J Hepatol 2012 Apr 17. [Epub ahead of print] (IF 9.334).
  • Langman CB, Greenbaum LA, Sarwal M, Grimm P, Niaudet P, Deschênes G, Cornelissen E, Morin D, Cochat P, Matossian D, Gaillard S, Bagger MJ, Rioux. (2012) A Randomized Controlled Crossover Trial with Delayed-Release Cysteamine Bitartrate in Nephropathic Cystinosis: Effectiveness on White Blood Cell Cystine Levels and Comparison of Safety. Clin J Am Soc Nephrol 2012 May 10, [Epub ahead of print] (IF 4.763).
  • Breton M, Farret A, Bruttomesso D, Anderson S, Magni L, Patek S, Dalla Man C, Place J, Demartini S, Del Favero S, Toffanin C, Hughes C, Dassau E, Zisser H, Doyle FJ III, De Nicolao G, Avogaro A, Cobelli C, Renard E, Kovatchev B, on behalf of The International Artificial Pancreas (iAP) Study Group. Fully-integrated artificial pancreas in type 1 diabetes: modular closed-loop glucose control maintains near-normoglycemia. Diabetes; 2012 Jun 11. [Epub ahead of print] (IF 8.889).
  •  Mura T, Proust-Lima C, Akbaraly T, Amieva H, Tzourio C, Chevassus H, Picot MC, Jacqumin-Gadda H, Berr C. Chronic use of benzodiazepines and latent cognitive decline in the elderly: Results from the Three-city study. Eur Neuropsychopharmacol 2012 Jun 15. [Epub ahead of print] (IF 4.201) 
  • Cobelli C, Renard E, Kovatchev BP, Keith-Hynes P, Ben Brahim N, Place J, Del Favero S, Breton M, Farret A, Bruttomesso D, Dassau E, Zisser H, Doyle III FJ, Patek SD, Avogaro A. First Clinical Experience with a Wearable Artificial Pancreas System Allowing Ambulatory Glucose Control in Patients with Type 1 Diabetes. Diabetes Care; 2012, In Press (IF 7.141).
  •  Galtier F, Mura T, E Raynaud de Mauverger,Chevassus H, A Farret, JP Gagnol, F Costa, A Dupuy, P Petit, JP Cristol, J Mercier, A Lacampagne. Effect of a high dose of simvastatin on muscle mitochondrial metabolism and calcium signaling in healthy volunteers. Toxicology and applied pharmacology 2012, Accepted (IF 3.993).
  •  H Laurichesse, U Zimmermann, Galtier F, O Launay, X Duval, P Richard, C Sadorge, B Soubeyrand. Immunogenicity and safety results from a randomized multicentre trial comparing a Tdap-IPV vaccine (REPEVAX®) and a tetanus monovalent vaccine in healthy adults: new considerations for the management of patients with tetanus prone injuries. Human Vaccines, 2012;8:12. (IF 3.577).
  •  Guichet PO, Bieche I, Teigell M, Serguera C, Rothhut B, Rigau V, Scamps F, Ripoll C, Vacher S, Taviaux S, Chevassus H, Duffau H, Mallet J, Susini A, Joubert D, Bauchet L, Hugnot JP. Cell death and neuronal differentiation of glioblastoma stem-like cells induced by neurogenic transcription factors. Glia. 2012 Oct 9. doi: 10.1002/glia.22429. [Epub ahead of print] (IF 4.820) 
  • Morquin D, Le Moing V, Mura T, Makinson A, Klouche K, Jonquet O, Reynes J, Corne P. Short- and long-term outcomes of HIV-infected patients admitted to the intensive care unit: impact of antiretroviral therapy and immunovirological status. Ann Intensive Care 2012;2(1):25. 
  • Riveline JP, Schaepelynck P, Chaillous L, Renard E, Sola-Gazagnes A, Penfornis A, Tubiana-Rufi N, Sulmont V, Catargi B, Lukas C, Radermecker RP, Thivolet C, Moreau F, Benhamou PY, Guerci B, Leguerrier AM, Millot L, Sachon C, Charpentier G, Hanaire H (2012) Assessment of patient-led or physician-driven continuous glucose monitoring in patients with poorly controlled type 1 diabetes using basal-bolus insulin regimens: a 1-year multicenter study. Diabetes Care 35:965-971. (IF 8.087). 
  • Portales P, Psomas KC, Tuaillon E, Mura T, Vendrell JP, Eliaou JF, Reynes J, Corbeau P. The intensity of immune activation is linked to the level of CCR5 expression in human immunodeficiency virus type 1-infected persons. Immunology 2012;137(1):89-97 (IF3.23).
  •  Baghdadli A, Assouline B, Sonie S, Pernon E, Darrou C, Michelon C, Picot MC, Aussilloux C and Pry R. Developmental trajectories of adaptive behaviors from early childhood to adolescence in a cohort of 152 children with autism spectrum disorders. J Autism Dev Disord. 2011 1314-25 (IF: 3.699 SIGAPS: B).
  • Guétin S, Giniès P, Siou DK, Picot MC, Pommié C, Guldner E, et al. The effects of music intervention in the management of chronic pain: a single-blind, randomized, controlled trial. Clin J Pain 2012;28:329-37. (IF:2.552 SIGAPS:C).
  •  Rideau Batista Novais A, Matecki S, Jaussent A,Picot MC, Amedro P, Guillaumont S, et al. Hyperventilation during exercise in very low birth weight school-age children may implicate inspiratory muscle weakness. J Pediatr 2012;160:415-420 (IF:4.035 SIGAPS:A ).
  • Mourand I, Escuret E, Héroum C, Jonquet O, Picot MC, Mercier G, et al. Feasibility of hypothermia beyond 3 weeks in severe ischemic stroke: an open pilot study using ?-hydroxybutyrate. J Neurol Sci 2012;316:104-7. (IF:2.243 SIGAPS:D ).
  •   Dupuy-Bonafé I, Picot MC, Maldonado IL, Lachiche V, Granier I, Bonafé A. Internal derangement of the temporomandibular joint: is there still a place for ultrasound? Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:832-40. (IF:1.495 SIGAPS:C).
  •   Sterkers Y, Pratlong F, Albaba S, Loubersac J, Picot MC, Pretet V, et al. Novel interpretation of molecular diagnosis of congenital toxoplasmosis according to gestational age at the time of maternal infection. J Clin Microbiol 2012;50:3944-51. (IF:4.068 SIGAPS:B) 
  •  Mura T, Picaud JC, Larroque B, Galtier F, Marret S, Roze JC, Truffert P, Kuhn P, Fresson J, Thiriez G, Arnaud C, Mercier G, Picot MC, Ancel PY, Ledesert B. Cognitive Impairment at Age 5 Years in Very Preterm Infants Born Following Premature Rupture of Membranes. J Pediatr 2013;9(13):00114-5. (IF: 4.115). 
  • Chevassus H, Farret A, Gagnol JP,, Poncon CA, Costa F, Roux C, Galtier F, Petit P,. Psychological and physiological effects of bupropion compared to methylphenidate after prolonged administration in healthy volunteers (NCT00285155). Eur J Clin Pharmacol. 2013;69(4):779-87. doi: 10.1007/s00228-012-1418-z. Epub 2012 Oct 9. (IF: 3.993).
  • Maimoun L, Coste O, Philibert P, Briot K, Mura T, Galtier F, Mariano-Goulart D, Paris F, Sultan C. Peripubertal female athletes in high-impact sports show improved bone mass acquisition and bone geometry. Metabolism 2013;11(13):00042-5. (IF: 2.664).
  • Maimoun L, Coste O, Philibert P, Briot K, Mura T, Galtier F, Crastes-de-Paulet B, Mariano-Goulart D, Sultan C, Paris F. Testosterone secretion in elite adolescent swimmers does not modify bone mass acquisition: a 1-year follow-up study. Fertil Steril. 2013;99(1):270-8.(IF: 3.775). 
  • Daien CI, Fesler P, du Cailar G, Daien V, Mura T, Dupuy AM, Cristol JP, Ribstein J, Combe B, Morel J. Etanercept normalises left ventricular mass in patients with rheumatoid arthritis. Ann Rheum Dis 2012. [Epub ahead of print] (IF 8.72). 
  • McElhaney JE, Beran J, Devaster JM, Esen M, Launay O, Leroux-Roels G, Ruiz-Palacios GM, van Essen GA, Caplanusi A, Claeys C, Durand C, Duval X, El Idrissi M, Falsey AR, Feldman G, Frey SE, Galtier F, Hwang SJ, Innis BL, Kovac M, Kremsner P, McNeil S, Nowakowski A, Richardus JH, Trofa A, Oostvogels L. AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: a phase 3 randomised trial. Lancet Infect Dis 2013;18(13):70046-X. (IF: 17.391).
  • Maimoun L, Coste O, Mura T, Philibert P, Galtier F, Mariano-Goulard D, Paris F, Sultan C. Specific bone mass acquisition in elite female athletes. J Clin Endocrinol Metab. 2013 Jul;98(7):2844-53. (IF: 5.967).
  • Launay O, Paul S, Servettaz A, Roguet G, Rozenberg F, Lucht F, Lambert C, Presles E, Goulvestre C, Meritet J-F, Galtier F, Dubray C, Lebon P, Weill B, Batteux F. Control of humoral immunity and auto-immunity by 1 the CXCR4/CXCL12 2 axis in lupus patients following influenza vaccine. Vaccine 2013; 31(35):3492-501. (IF: 3.770).
  • McElhaney JE, Beran J, Devaster JM, Esen M, Launay O, Leroux-Roels G, Ruiz-Palacios GM, van Essen GA, Caplanusi A, Claeys C, Durand C, Duval X, El Idrissi M, Falsey AR, Feldman G, Frey SE, Galtier F, Hwang SJ, Innis BL, Kovac M, Kremsner P, McNeil S, Nowakowski A, Richardus JH, Trofa A, Oostvogels L. AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: a phase 3 randomised trial. Lancet Infect Dis 2013;18(13):70046-X. (IF: 17.391).
  • Maimoun L, Coste O, Mura T, Philibert P, Galtier F, Mariano-Goulard D, Paris F, Sultan C. Specific bone mass acquisition in elite female athletes. J Clin Endocrinol Metab. 2013 Jul;98(7):2844-53. (IF: 5.967).
  • Launay O, Paul S, Servettaz A, Roguet G, Rozenberg F, Lucht F, Lambert C, Presles E, Goulvestre C, Meritet J-F, Galtier F, Dubray C, Lebon P, Weill B, Batteux F. Control of humoral immunity and auto-immunity by 1 the CXCR4/CXCL12 2 axis in lupus patients following influenza vaccine. Vaccine 2013; 31(35):3492-501. (IF: 3.770).
  •  Kovatchev BP, Renard E, Cobelli C, Zisser HC, Keith-Hynes P, Anderson SM, Brown SA, Chernavvsky DR, Breton MD, Farret A, Pelletier MJ, Place J, Bruttomesso D, M Del Favero S, Visentin R , Filippi A, Scotton R, Avogaro A, Doyle FJ III. Feasibility of outpatient fully integrated closed-loop control: First studies of wearable artificial pancreas. Diabetes Care, in press, 2013. (IF 8.087).
  • Luijf YM, Arnolds S, Avogaro A, Benesch C, Bruttomesso D, Farret A, Heinemann L, Place J, Renard E, Scotton R, Devries JH On Behalf Of The AP Home Consortium (2013) Patch Pump Versus Conventional Pump: Postprandial Glycemic Excursions and the Influence of Wear Time. Diabetes Technol Ther May 7. [Epub ahead of print] (IF 1.931).
  • Luijf YM, Mader JK, Doll W, Pieber T, Farret A, Place J, Renard E, Bruttomesso D, Filippi A, Avogaro A, Arnolds S, Benesch C, Heinemann L, Devries JH On Behalf Of The AP Home Consortium (2013) Accuracy and Reliability of Continuous Glucose Monitoring Systems: A Head-to-Head Comparison. Diabetes Technol Ther. May 7. [Epub ahead of print] (IF 1.931) .
  • Radermecker RP, Fayolle C, Brun JF, Bringer J, Renard E, (2013) Accuracy assessment of online glucose monitoring by a subcutaneous enzymatic glucose sensor during exercise in patients with type 1 diabetes treated by continuous subcutaneous insulin infusion. Diabetes Metab. Mar 19. doi:pii: S1262-3636(13)00011-6. 10.1016/j.diabet.2012.12.004. [Epub ahead of print] (IF 2.411) .
  • Hervé MJ, Jaussent A, Paradis M, Rattaz C, Lopez S, Evrard V, Picot MC, Maury M. Troubles du comportement et troubles fonctionnels du nourrisson : caractéristiques, interactions mère-enfant, alliance et évolution après une psychothérapie brève parent-enfant. Étude pilote. Encephale 2013;39:29-37. (IF: 0.493).
  •  Milesi C, Matecki S, Jaber S, Mura T, Jacquot A, Pidoux O, Chautemps N, Rideau Batista Novais A, Combes C, Picaud JC, Cambonie G. 6 cmH(2) O continuous positive airway pressure versus conventional oxygen therapy in severe viral bronchiolitis: A randomized trial. Pediatr Pulmonol 2013 Jan;48(1):45-51. (IF 2.53) .
  • Renard E, Proust-Lima C, Jacqmin-Gadda H, Akbaraly TN, Dubois B and Berr C. Measuring cognitive change in subjects with prodromal Alzheimer disease. in press J Neurol Neurosurg Psychiatry. 2013 (IF 4.76).
  • Reme T, Joubert D, Hugnot JP, Bauchet L, Duffau H, Rigau V, Bieche I, Burel-Vandenbos F, Prevot V, Baroncini M, Fontaine D, Chevassus H, Vacher S, Lidereau R. A molecular predictor reassesses classification of human grade II/III gliomas. Plos One 2013, in press (IF 4.092) .
  • L Maïmoun, O Coste, NA. Georgopoulos, ND. Roupas ,KK Mahadea, A Tsouka, Mura T, P Philibert , L Gaspari, D Mariano-Goulart , M Leglise and C Sultan. Despite a high prevalence of menstrual disorders, bone status is improved in worldclass female rhythmic gymnasts J Clin Endocrinol Metab 2013;in press. (IF: 5.967).
  •  Humbertclaude V, Hamroun D, Picot MC, Bezzou K, Bérard C, Boespflug-Tanguy O, Bommelaer C, Campana-Salort E, Cances C, Chabrol B, Commare MC, Cuisset JM, de Lattre C, Desnuelle C, Echenne B, Halbert C, Jonquet O, Labarre-Vila A, N'guyen-Morel MA, Pages M, Pepin JL, Petitjean T, Pouget J, Ollagnon-Roman E, Richelme C, Rivier F, Sacconi S, Tiffreau V, Vuillerot C, Béroud C, Tuffery-Giraud S, Claustres M. Phenotypic heterogeneity and phenotype-genotype correlations in dystrophinopathies: Contribution of genetic and clinical databases. Rev Neurol (Paris). 2013 Aug 14. pii: S0035-3787(13)00838-2. doi: 10.1016/j.neurol.2013.04.004. [Epub ahead of print] (IF: 0.51 SIGAPS: E).
  •  Baghdadli A, Brisot J, Henry V, Michelon C, Soussana M, Rattaz C and Picot MC,. Social skills improvement in children with high-functioning autism: a pilot randomized controlled trial. Eur Child Adolesc Psychiatry 2013 Jul;22(7):433-42 (IF: 3.699 SIGAPS: B).
  •  Mourand I, Machi P, Milhaud D, Picot MC, Lobotesis K, Arquizan C, Costalat V, Héroum C, Sablot D, Bouly S, Lalu T, Bonafé A. Mechanical thrombectomy with the Solitaire device in acute basilar artery occlusion. J Neurointerv Surg 2013 May 4. [Epub ahead of print] (IF: 1.378 SIGAPS: D) .
  • Pujol P, Lyonnet DS, Frebourg T, Blin J, Picot MC, Lasset C, Dugast C, Berthet P, de Paillerets BB, Sobol H, Grandjouan S, Soubrier F, Buecher B, Guimbaud R, Lidereau R, Jonveaux P, Houdayer C, Giraud S, Olschwang S, Nogue E, Galibert V, Bara C, Nowak F, Khayat D, Nogues C. Lack of referral for genetic counseling and testing in BRCA1/2 and Lynch syndromes: a nationwide study based on 240,134 consultations and 134,652 genetic tests. Breast Cancer Res Treat (2013) 141:135?144 (IF: 4.469 SIGAPS: B).
  •  Lefebvre P, Letois F, Sultan A, Nocca D, Mura T, Galtier F,. Nutrient deficiencies in subjects with obesity considering bariatric surgery: a cross-sectional study. SOARD, in press. (IF: 4.121).

Brevets

  • Chevassus H, Petit P, Renard E, Galtier F, Farret F, (2006 / 2011) Produit utilisé en tant que complément alimentaire ou médicament, destiné à réduire la prise de lipides dans l'alimentation, et utilisation de ce produit. Brevet français n° 06 50178 du 18 Janvier 2006 délivré le 15 avril 2011, publié le 15 avril 2011 au Bulletin Officiel de la Propriété Industrielle n°11/15 sous le n° 2 896 163.