Recherche

Le service d'ophtalmologie du CHU de Montpellier est spécialisé dans l'épidémiologie et les facteurs de risque des maladies oculaires.

Notre département a des personnels dédiés à la recherche et mène différentes recherches sur des maladies oculaires incluant la dégénérescence maculaire, la rétinopathie diabétique, le kératocône et le glaucome.

Nous collaborons avec de nombreuses équipes en France (Bordeaux, Dijon, Paris...) et à l'international (Australie, Suisse, Japon, Angleterre...).

Nos projets en cours

Les registres

Les registres des maladies sont utilisés comme un outil d'observation pour évaluer les résultats chez des patients du monde réel.

En surveillant les patients sous soins de routine, les études observationnelles peuvent aider à mieux comprendre la progression de la maladie et les besoins non satisfaits des patients, ce qui se traduit par des schémas thérapeutiques plus efficaces.

Les Save Sight Registries visent à rassembler l'expertise académique et de recherche des institutions collaboratrices du monde entier pour établir un réseau international visant à améliorer la qualité de prise en charge des maladies oculaires. Les registres contiennent déjà 10 ans de données sur les résultats du traitement ophtalmique et suit 30 000 yeux.

Les Save Sight Registries incluent Fight Retinal Blindness! (FRB!), Fight Corneal Blindness! (FCB!), Fight Glaucoma Blindness! et Fight Tumor Blindness! (FTB!).

Nous contribuons également au Registre européen des greffes de cornée.  Ce registre Européen vise à analyser l'innocuité, la qualité et l'efficacité des transplantations ophtalmiques.

Les études cliniques

Film lacrymal et physiopathologie cornéenne (FiLaPhyCo)

Nous avons commencé le recrutement pour le projet FiLaPhyCo en collaboration avec l'université de Montpellier et l'Institut de Neurosciences de Montpellier.

Il s’agit d’une recherche observationnelle, pour laquelle nous analyserons les larmes des patients ayant une lésion de la cornée.

L’objectif de cette étude est de déterminer le profil protéomique associé à la cicatrisation cornéenne normale. A plus long terme, mieux connaître les facteurs de cicatrisation pourrait servir de support aux traitements lors de la cicatrisation cornéenne pathologique.

Participer aux études

Nous recherchons actuellement des volontaires pour participer aux études.

Si vous êtes intéressé à participer à l'une de nos recherches ou souhaitez plus d'informations, veuillez nous contacter directement au 04 67 33 79 62 ou par e-mail .

Publications

Les principales publications scientifiques du service sont ci-dessous : 

• DAIEN V, Nguyen V, Morlet N, Arnold JJ, Essex RW, Young S, Hunyor A, Gillies MC, Barthelmes D; Fight Retinal Blindness! Study Group. Outcomes and predictive factors after cataract surgery in patients with neovascular age-related macular degeneration. The Fight Retinal Blindness! Project. Am J Ophthalmol. 2018 Mar 14. pii: S0002-9394(18)30110-7. doi: 10.1016/j.ajo.2018.03.012. [Epub ahead of print] PMID: 29550186.
• Mehta H, Tufail A, DAIEN V, Lee AY, Nguyen V, Ozturk M, Barthelmes D, Gillies MC. Real-world outcomes in patients with neovascular age-related macular degeneration treated with intravitreal vascular endothelial growth factor inhibitors. Prog Retin Eye Res. 2018 Jan 2. pii: S1350-9462(17)30105-2. doi: 10.1016/j.preteyeres.2017.12.002. [Epub ahead of print] Review. PMID: 29305324
• Nguyen V, DAIEN V, Guymer RH, McAllister IL, Morlet N, Barthelmes D, Gillies MC. Clinical and social characteristics associated with reduced visual acuity at presentation in Australian patients with neovascular age-related macular degeneration: a prospective study from a long term observational dataset. The Fight Retinal Blindness Project. Clin Exp Ophthalmol. 2017 Aug 25. doi: 10.1111/ceo.13038. [Epub ahead of print] PubMed PMID: 28842956.
• Vaze A, Nguyen V, DAIEN V, Arnold JJ, Young SH, Cheung CM, Lamoureux E, Bhargava M, Barthelmes D, Gillies MC; Fight Retinal Blindness Study Group.. RANIBIZUMAB AND AFLIBERCEPT FOR THE TREATMENT OF PIGMENT EPITHELIAL DETACHMENT IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: Data from an Observational Study. Retina. 2017 Aug 16. [Epub ahead of print] PubMed PMID: 28820848.
• DAIEN V, Nguyen V, Essex RW, Morlet N, Barthelmes D, Gillies MC; Fight Retinal Blindness! Study Group.. Incidence and Outcomes of Infectious and Noninfectious Endophthalmitis after Intravitreal Injections for Age-Related Macular Degeneration. Ophthalmology. 2017 Aug 8. pii: S0161-6420(17)30747-9. doi: 10.1016/j.ophtha.2017.07.005. [Epub ahead of print] PubMed PMID: 28801117.
• Babeau F, Busetto T, Hamel C, Villain M, DAIEN V. Adaptive optics: a tool for screening hydroxychloroquine-induced maculopathy? Acta Ophthalmol. 2017 Aug;95(5):e424-e425. doi: 10.1111/aos.13276. Epub 2016 Nov 2. PubMed PMID: 27805308.
• Colijn JM, Buitendijk GHS, Prokofyeva E, Alves D, Cachulo ML, Khawaja AP, Cougnard-Gregoire A, Merle BMJ, Korb C, Erke MG, Bron A, Anastasopoulos E, Meester-Smoor MA, Segato T, Piermarocchi S, de Jong PTVM, Vingerling JR; EYE-RISK consortium., Topouzis F, Creuzot-Garcher C, Bertelsen G, Pfeiffer N, Fletcher AE, Foster PJ, Silva R, Korobelnik JF, Delcourt C, Klaver CCW; European Eye Epidemiology (E3) consortium.. Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future. Ophthalmology. 2017 Jul 14. pii: S0161-6420(16)32475-7. doi: 10.1016/j.ophtha.2017.05.035. [Epub ahead of print] PubMed PMID: 28712657.
• DAIEN V, Granados L, Kawasaki R, Villain M, Ribstein J, Du Cailar G, Mimran A, Fesler P. Retinal vascular caliber associated with cardiac and renal target organ damage in never-treated hypertensive patients. Microcirculation. 2017 May;24(4). doi: 10.1111/micc.12344. PubMed
• Pérès K, Matharan F, DAIEN V, Nael V, Edjolo A, Bourdel-Marchasson I 1st, Ritchie K, Tzourio C, Delcourt C, Carrière I. Visual Loss and Subsequent Activity Limitations in the Elderly: The French Three-City Cohort. Am J Public Health. 2017 Apr;107(4):564-569. doi: 10.2105/AJPH.2016.303631. Epub 2017 Feb 16. PubMed PMID: 28207341.
• Naël V, Pérès K, Carrière I, DAIEN V, Scherlen AC, Arleo A, Korobelnik JF, Delcourt C, Helmer C. Visual Impairment, Undercorrected Refractive Errors, and Activity Limitations in Older Adults: Findings From the Three-City Alienor Study. Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2359-2365. doi: 10.1167/iovs.17-21525. PubMed PMID: 28437525.
• Bron AM, Mariet AS, Benzenine E, Arnould L, DAIEN V, Korobelnik JF, Quantin C, Creuzot-Garcher C. Trends in operating room-based glaucoma procedures in France from 2005 to 2014: a nationwide study. Br J Ophthalmol. 2017 Mar 14. pii: bjophthalmol-2016-309946. doi: 10.1136/bjophthalmol-2016-309946. [Epub ahead of print] PubMed PMID: 28292777.
• DAIEN V, Mura F, Martin G, Audo R, Rivière S, Konate A, Morel J, Villain M, Hahne M, Schneider C, DAIEN C. Th17 and regulatory T cells are increased in blood of patients with birdshot chorioretinopathy. Acta Ophthalmol. 2017 Mar;95(2):e161-e163. doi: 10.1111/aos.12949. Epub 2016 Mar 24. PubMed PMID: 27009556.
• Gillies MC, DAIEN V, Nguyen V, Barthelmes D. Re: Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) Research Group, et al.: Five-year outcomes with anti-vascular endothelial growth factor treatment of neovascular age-related macular degeneration: The Comparison of Age-Related Macular Degeneration Treatments Trials (Ophthalmology 2016;123:1751-1761). Ophthalmology. 2017 Mar;124(3):e31-e32. doi: 10.1016/j.ophtha.2016.05.054. PubMed PMID: 28219517.
• Plat J, Hoa D, Mura F, Busetto T, Schneider C, Payerols A, Villain M, DAIEN V. Clinical and biometric determinants of actual lens position after cataract surgery. J Cataract Refract Surg. 2017 Feb;43(2):195-200. doi: 10.1016/j.jcrs.2016.11.043. PubMed PMID: 28366366.
• Barthelmes D, Nguyen V, DAIEN V, Campain A, Walton R, Guymer R, Morlet N, Hunyor AP, Essex RW, Arnold JJ, Gillies MC; Fight Retinal Blindness Study Group.. TWO YEAR OUTCOMES OF "TREAT AND EXTEND" INTRAVITREAL THERAPY USING AFLIBERCEPT PREFERENTIALLY FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. Retina. 2017 Jan 31. doi: 10.1097/IAE.0000000000001496. [Epub ahead of print] PubMed PMID: 28145976.
• DAIEN V, Korobelnik JF, Delcourt C, Cougnard-Gregoire A, Delyfer MN, Bron AM, Carrière I, Villain M, Daures JP, Lacombe S, Mariet AS, Quantin C, Creuzot-Garcher C. French Medical-Administrative Database for Epidemiology and Safety in Ophthalmology (EPISAFE): The EPISAFE Collaboration Program in Cataract Surgery. Ophthalmic Res. 2017;58(2):67-73. doi: 10.1159/000456721. Epub 2017 Apr 4. PubMed PMID: 28376478.
• DAIEN V, Le Pape A, Heve D, Villain M, Bremond Gignac D; Collaborators of the Epidemiology and Safety Program (EPISAFE).. Incidence and Characteristics of Congenital Cataract Surgery in France from 2010 to 2012: The EPISAFE Program. Ophthalmic Res. 2017;58(2):114-116. doi: 10.1159/000473701. Epub 2017 Jun 20. PubMed PMID: 28633137.
• DAIEN V, Villain M, Creuzot-Garcher C. Comparison of Recent Studies of Postoperative Endophthalmitis From the Same National Database-Reply. JAMA Ophthalmol. 2016 Dec 29. doi: 10.1001/jamaophthalmol.2016.5107. [Epub ahead of print] PubMed PMID: 28033434.
• Gillies MC, Nguyen V, DAIEN V, Arnold JJ, Morlet N, Barthelmes D. Twelve-Month Outcomes of Ranibizumab vs. Aflibercept for Neovascular Age-Related Macular Degeneration: Data from an Observational Study. Ophthalmology. 2016 Dec;123(12):2545-2553. doi: 10.1016/j.ophtha.2016.08.016. Epub 2016 Oct 1. PubMed PMID: 27707549.
• Khawaja AP, Springelkamp H, Creuzot-Garcher C, Delcourt C, Hofman A, Höhn R, Iglesias AI, Wolfs RC, Korobelnik JF, Silva R, Topouzis F, Williams KM, Bron AM, Buitendijk GH, Cachulo MD, Cougnard-Grégoire A, Dartigues JF, Hammond CJ, Pfeiffer N, Salonikiou A, van Duijn CM, Vingerling JR, Luben RN, Mirshahi A, Lamparter J, Klaver CC, Jansonius NM, Foster PJ; European Eye Epidemiology (E³) Consortium.. Associations with intraocular pressure across Europe: The European Eye Epidemiology (E³) Consortium. Eur J Epidemiol. 2016 Nov;31(11):1101-1111. doi: 10.1007/s10654-016-0191-1. Epub 2016 Sep 9. PubMed PMID: 27613171; PubMed Central PMCID: PMC5206267.
• Grenier J, Meunier I, DAIEN V, Baudoin C, Halloy F, Bocquet B, Blanchet C, Delettre C, Esmenjaud E, Roubertie A, Lenaers G, Hamel CP. WFS1 in Optic Neuropathies: Mutation Findings in Nonsyndromic Optic Atrophy and Assessment of Clinical Severity. Ophthalmology. 2016 Sep;123(9):1989-98. doi: 10.1016/j.ophtha.2016.05.036. Epub 2016 Jul 7. PubMed PMID: 27395765.
• DAIEN V, Papinaud L, Gillies MC, Domerg C, Nagot N, Lacombe S, Daures JP, Carriere I, Villain M. Effectiveness and Safety of an Intracameral Injection of Cefuroxime for the Prevention of Endophthalmitis After Cataract Surgery With or Without Perioperative Capsular Rupture. JAMA Ophthalmol. 2016 Jul 1;134(7):810-6. doi: 10.1001/jamaophthalmol.2016.1351. PubMed PMID: 27136069.
• Verhaeghe F, Villain M, Labauge P, DAIEN V. Orbital Apex Syndrome Secondary to Herpes Zoster Ophthalmicus. J Neuroophthalmol. 2016 Jun;36(2):147-51. doi: 10.1097/WNO.0000000000000349. PubMed PMID: 26928600.
• Payerols A, Eliaou C, Trezeguet V, Villain M, DAIEN V. Accuracy of PlusOptix A09 distance refraction in pediatric myopia and hyperopia. BMC Ophthalmol. 2016 Jun 1;16:72. doi: 10.1186/s12886-016-0247-8. PubMed PMID: 27246869; PubMed Central PMCID: PMC4888737.
• Saumet L, Haouy S, DAIEN V, Hillaire-Buys D, Roessler J, Sirvent N. [Isolated unilateral cranial nerve palsy during childhood acute lymphoblastic leukemia treatment: What does it mean?]. Arch Pediatr. 2016 Apr;23(4):415-6. doi: 10.1016/j.arcped.2016.01.008. Epub 2016 Mar 8. French. PubMed PMID: 26968305.
• DAIEN V, Papinaud L, Domerg C, Lacombe S, Daures JP, Villain M. Incidence and Characteristics of Cystoid Macular Edema after Cataract Surgery. Ophthalmology. 2016 Mar;123(3):663-4. doi: 10.1016/j.ophtha.2015.10.009. Epub 2015 Nov 7. PubMed PMID: 26560833.
• Delcourt C, Korobelnik JF, Buitendijk GH, Foster PJ, Hammond CJ, Piermarocchi S, Peto T, Jansonius N, Mirshahi A, Hogg RE, Bretillon L, Topouzis F, Deak G, Grauslund J, Broe R, Souied EH, Creuzot-Garcher C, Sahel J, DAIEN V, Lehtimäki T, Hense HW, Prokofyeva E, Oexle K, Rahi JS, Cumberland PM, Schmitz-Valckenberg S, Fauser S, Bertelsen G, Hoyng C, Bergen A, Silva R, Wolf S, Lotery A, Chakravarthy U, Fletcher A, Klaver CC. Ophthalmic epidemiology in Europe: the "European Eye Epidemiology" (E3) consortium. Eur J Epidemiol. 2016 Feb;31(2):197-210. doi: 10.1007/s10654-015-0098-2. Epub 2015 Dec 19. PubMed PMID: 26686680.
• Contín MA, Benedetto MM, Quinteros-Quintana ML, Guido ME. Light pollution: the possible consequences of excessive illumination on retina. Eye (Lond). 2016 Feb;30(2):255-63. doi: 10.1038/eye.2015.221. Epub 2015 Nov 6. Review. PubMed PMID: 26541085; PubMed Central PMCID: PMC4763120.
• DAIEN V, Le Pape A, Heve D, Carriere I, Villain M. Incidence, Risk Factors, and Impact of Age on Retinal Detachment after Cataract Surgery in France: A National Population Study. Ophthalmology. 2015 Nov;122(11):2179-85. doi: 10.1016/j.ophtha.2015.07.014. Epub 2015 Aug 13. PubMed PMID: 26278859.
• Chassine T, Bocquet B, DAIEN V, Avila-Fernandez A, Ayuso C, Collin RW, Corton M, Hejtmancik JF, van den Born LI, Klevering BJ, Riazuddin SA, Sendon N, Lacroux A, Meunier I, Hamel CP. Autosomal recessive retinitis pigmentosa with RP1 mutations is associated with myopia. Br J Ophthalmol. 2015 Oct;99(10):1360-5. doi: 10.1136/bjophthalmol-2014-306224. Epub 2015 Apr 16. PubMed PMID: 25883087.
• DAIEN V, Le Pape A, Heve D, Carriere I, Villain M. Incidence and Characteristics of Cataract Surgery in France from 2009 to 2012: A National Population Study. Ophthalmology. 2015 Aug;122(8):1633-8. doi: 10.1016/j.ophtha.2015.04.017. Epub 2015 Jun 4. PubMed PMID: 26050539.
• Chassine T, Villain M, Hamel CP, DAIEN V. How can we prevent myopia progression? Eur J Ophthalmol. 2015 Jul-Aug;25(4):280-5. doi: 10.5301/ejo.5000571. Epub 2015 Feb 3. Review. PubMed PMID: 25655598.
• DAIEN V, Peres K, Villain M, Colvez A, Carriere I, Delcourt C. Visual acuity thresholds associated with activity limitations in the elderly. The Pathologies Oculaires Liées à l'Age study. Acta Ophthalmol. 2014 Nov;92(7):e500-6. doi: 10.1111/aos.12335. Epub 2014 Jan 16. PubMed PMID: 24428942.
• Donnadieu-Rigole H, DAIEN V, Blanc D, Michau S, Villain M, Nalpas B, Perney P. The prevalence of optic neuropathy in alcoholic patients--a pilot study. Alcohol Clin Exp Res. 2014 Jul;38(7):2034-8. doi: 10.1111/acer.12468. Epub 2014 Jun 24. PubMed PMID: 24961289.
• DAIEN V, Carriere I, Kawasaki R, Cristol JP, Villain M, Fesler P, Ritchie K, Delcourt C; POLA Study Group.. Malnutrition and retinal vascular caliber in the elderly: the POLA study. Invest Ophthalmol Vis Sci. 2014 May 27;55(7):4042-9. doi: 10.1167/iovs.13-13721. PubMed PMID: 24867580.
• Carrière I, Delcourt C, DAIEN V, Pérès K, Féart C, Berr C, Ancelin ML, Ritchie K. A prospective study of the bi-directional association between vision loss and depression in the elderly. J Affect Disord. 2013 Oct;151(1):164-70. doi: 10.1016/j.jad.2013.05.071. Epub 2013 Jun 17. PubMed PMID: 23787409.
• DAIEN V, Kawasaki R, Villain M, Ribstein J, Du Cailar G, Mimran A, Fesler P.
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• Retinal vascular caliber is associated with renal function in apparently healthy subjects. Acta Ophthalmol. 2013 Jun;91(4):e283-8. doi: 10.1111/aos.12094. Epub 2013 Feb 14. PubMed PMID: 23406335.
• DAIEN V, Turpin C, Lignereux F, Belghobsi R, Le Meur G, Lebranchu P, Pechereau A. Determinants of ocular deviation in esotropic subjects under general anesthesia. J Pediatr Ophthalmol Strabismus. 2013 May-Jun;50(3):155-60. doi: 10.3928/01913913-20130226-01. Epub 2013 Mar 5. PubMed PMID: 23451722.
• DAIEN V, Carriere I, Kawasaki R, Cristol JP, Villain M, Fesler P, Ritchie K, Delcourt C. Retinal vascular caliber is associated with cardiovascular biomarkers of oxidative stress and inflammation: the POLA study. PLoS One. 2013 Jul 26;8(7):e71089. doi: 10.1371/journal.pone.0071089. Print 2013. PubMed PMID: 23923054; PubMed Central PMCID: PMC3724806.
• DAIEN V, Allieu S. [Congenital retinal macrovessel]. J Fr Ophtalmol. 2012 Dec;35(10):852-3. doi: 10.1016/j.jfo.2012.04.010. Epub 2012 Oct 4. French. PubMed PMID: 23040444.
• DAIEN V, Navarre S, Fesler P, Vergely L, Villain M, Schneider C. Visual acuity outcome and predictive factors after bevacizumab for central retinal vein occlusion. Eur J Ophthalmol. 2012 Nov-Dec;22(6):1013-8. doi: 10.5301/ejo.5000162. Epub 2012 May 6. PubMed PMID: 22569812.
• DAIEN V, Duny Y, Ribstein J, du Cailar G, Mimran A, Villain M, Daures JP, Fesler P. Treatment of hypertension with renin-angiotensin system inhibitors and renal dysfunction: a systematic review and meta-analysis. Am J Hypertens. 2012 Jan;25(1):126-32. doi: 10.1038/ajh.2011.180. Epub 2011 Oct 13. Review. PubMed PMID: 21993366.
• DAIEN V, Malrieu eliaou C, Rodiere M, Rivier F, Dufier JL, Villain M. Juvenile xanthogranuloma with bilateral optic neuritis. Br J Ophthalmol. 2011 Sep;95(9):1331-2. doi: 10.1136/bjo.2009.171421. PubMed PMID: 20813747.
• DAIEN V, Pérès K, Villain M, Colvez A, Delcourt C, Carrière I. Visual impairment, optical correction, and their impact on activity limitations in elderly persons: the POLA study. Arch Intern Med. 2011 Jul 11;171(13):1206-7. doi: 10.1001/archinternmed.2011.140. Epub 2011 Apr 11. PubMed PMID: 21482828; PubMed Central PMCID: PMC3518795.
• Daïen V, Rivière S, Konaté A, Arnaud D, Villain M, Schneider C. [Acute diplopia after the age of 50; always look for giant cell arteritis]. J Fr Ophtalmol. 2009 Oct;32(8):579.e1-5. doi: 10.1016/j.jfo.2009.04.017. Epub 2009 Jun 16. French. PubMed PMID: 19535171.